3D Bioprinted Human Skin
Biology of the Human Skin & Innoskin®
3D Bioprinted Human Epidermis that is an alternative to animal models in cosmetic, chemical, agro-chemical and pharmaceutical testing applications.
How is Innoskin® HE Made?
Keratinocytes are added to our trade secret biomaterial mix in specific measured proportions to develop the perfect bioink to print human skin. The bioink is then loaded into the extruder for printing
The loaded bioink is bioprinted using our patented 3D Bioprinting technology in meticulously designed scaffold patterns to aid in optimal bioink deposition and uniform cell distribution throughout the scaffold
The printed scaffolds are carefully incubated for specific time periods to allow them to mature into fully formed epidermal tissues. The tissues are developed in our trade secret medias to give them the right nutritional conditions for growth
After complete maturation, the Innoskin® HE tissues would be shipped in customer specified formats for testing applications across industries
Why do we need Innoskin® HE?
Global Ban on Animal Testing
The European Union has completely banned the use of animals for testing cosmetic and chemical formulations
Implementation of this ban has pushed companies operating in these domains to look for more viable, effective and cruelty-free methodologies of testing. The current testing models for these companies are 3D Cultured Human Skin, Pig Skin and 2 dimensional cell cultures
Challenges faced with current models
End consumer prices for cadaver skin and 3D cultured skin is extremely high as these technologies lack the capability to scale up and bring down operation costs
Human intervention in the creation of 3D cultured models leads to gaps in the tissue and high batch to batch variability in testing results
Critical tissue architectural behaviours and features are different in pig skin and two dimensional skin tissues and are sub optimal in 3D cultured skin constructs
3D Bioprinted skin that comprises of the dermal and epidermal components.Innoskin® FT will be available in two variants – Innoskin® FT – NM, which will comprise of a skin construct without melanocytes (cells that provide skin colouration), and Innoskin® FT – M, which will comprise of precisely positioned melanocytes to accurately mimic natural skin colour. Both models will be ideal for diffusion testing applications in chemical, agrochemical, cosmetic and pharmaceutical R&D.
3D Bioprinted Human skin, complete with the intricate architecture, that is developed using patient’s own cells to treat wounds, burns and other skin related injuries and cosmetic corrections.